Furthermore, we also observed that IFNγ activation and cytotoxic activity of lymphocytes isolated from GC-treated mice not only reacted to graft MBT-2-luc cells but also to xenogeneic urothelial cells, suggesting that GC chemotherapy worked as cytotoxic agents and immune boosters to trigger anti-tumor immunity to reject tumor cells, which increased the body immunological rejection capacity to react to xenogeneic urothelial cells. The gene discussed is IFNG; the disease is neoplasm.