Tumor cells have many strategies to evade immunity either by downregulating the expression of tumor-specific or tumor-associated antigens on the cell surface, or inducing cells in the tumor microenvironment such as myeloid-derived suppressor cells or T regulatory cells to release cytokines, such as transforming growth factor beta (TGF-β), that suppress immune responses while promoting tumor cell proliferation and survival [22]. This evidence concerns the gene TGFB1 and neoplasm.