We further demonstrated the highest frequency of CDKN2A depletion among four datasets in lung cancer patients including PanCancer Atlas (Figure 1c), Nat Genet 2016 (Figure 1d), Provisional (Figure 1e), and Cancer Discov 2017 (Figure 1f), which indicated the universal genomic depletion of CDKN2A and its essential roles in the tumorigenesis of lung cancer. Here, CDKN2A is linked to lung cancer.