A study by Chang et al.117has demonstrated that high MYCN expression is present in 24 (39.3%) and ALK protein in 25 (41%) of the 61 NB tumors analyzed. A mechanistic study has indicated that ALK plays a role in the positive regulation of MYCN activity through suppression of HMG‐box transcription factor 1 (HBP1) expression in NB cells.118. This evidence concerns the gene HBP1 and neuroblastoma.