EPAS1 and neoplasm: Persson et al.263have investigated the effects of inhibiting ARNT (aryl hydrocarbon receptor nuclear translocator)‐dependent HIF‐2 induced transcription by PT2385, and found that PT2385 treatment inhibits the dimerization between ARNT and HIF‐2α, and also reduces the nuclear HIF‐2α protein levels under hypoxia in the NB PDX. However, the same study has shown that there are no effects on HIF‐2 target gene expression, and no major change is observed in the cell survival in vitro or on the in vivo tumor growth after PT2385 treatment.263