A study by Jögi et al.15has shown that hypoxia stabilizes both HIF‐1α and HIF‐2α in NB cells. The same study has also demonstrated that pretreatment of SK‐N‐BE(2) NB cells in vitro at 1% O2 cause the tumor cells to have a reduced tumor latency and increases the growth of subcutaneous xenografts compared with SK‐N‐BE(2) cells pretreated under normoxic culture conditions.15 This evidence concerns the gene HIF1A and neoplasm.