A study by Zhang et al.90, 91has shown that silencing WNT family member 1 (WNT1) expression by RNAi reduced the viability of SH‐SY5Y NB cells. Another study by Zins et al.92has shown that knockdown of frizzled class receptor 2 (FZD2) inhibits the proliferation of the NB SK‐N‐AS and SK‐N‐DZ cell lines, and reduces the WNT3A‐facilitated SK‐N‐DZ cell migration and WNT5A‐facilitated SK‐N‐AS cell migration. Wnt/β‐catenin signaling also plays a key role in the chemoresistance of NB cells. This evidence concerns the gene FZD2 and neuroblastoma.