Because miR‐34a‐5p was shown to be up‐regulated in patients with migraine, we down‐regulated miR‐34a‐5p by using its inhibitor, and then we detected the expression level of SIRT1, IL‐1β, miR‐34a‐5p, NF‐κB p65 and COX2 by quantitative real‐time PCR. Here, SIRT1 is linked to migraine disorder.