PTEN and posterior cortical atrophy: Collectively, BAP1 protein was positively correlated with PTEN protein, whereas both BAP1 and PTEN proteins showed negative associations with AKT_pT308 and AKT_pS473 in clinical PCa specimens (Fig. 7E), revealing that BAP1 made pivotal contribution to the PI3K/Akt signaling pathway through regulating PTEN in PCa progression.