Another constraint on the applicability of general recommendations for the surgical management of perforated diverticulitis with peritonitis is the different attitude of colorectal surgeons and non-colorectal specialists, who perform the vast majority of procedures for complicated diverticulitis [117, 118] but with significantly lower rates of PRA [117, 118] and LPL [118]. The gene discussed is LPL; the disease is diverticulitis.