The importance of C5AR1–RPS19 interaction for immunosuppression was recently demonstrated, showing that the downregulation of RPS19 in tumor cells or pharmacological blockade of C5AR1 by C5ARA reduced this immunosuppression and led to the generation of tumor-specific T-cell responses and slower tumor growth in breast and ovarian cancer cells [50]. The gene discussed is RPS19; the disease is ovarian cancer.