The single-cell characterization of proneural glioma evidenced that the concurrent expression of high levels of the PDGFA ligand by the abundant oligodendrocytes infiltrating PDGFRA-amplified proneural GBM provide the crucial initiating signaling event for the effects that this pathway has for proliferation, stemness, and progression of brain tumors [77]. The gene discussed is PDGFRA; the disease is central nervous system cancer.