The MDK–LRP2, which scored as top interaction among GBM tumor cells (ligand) and oligodendrocyte (receptor), is especially intriguing because overexpression of MDK (midkine) has been shown in several human tumors and recently was reported as a driver of aberrant proliferation, poor survival, and pharmacological resistance in human glioma [51]. This evidence concerns the gene LRP2 and central nervous system cancer.