At 4 months, insulinemia was higher in ApoE-KO ND group (p < 0.01) and also in ApoE-KO FD group (p < 0.0001), showing an additional rise in ApoE-KO FD group (p < 0.0001) compared with ApoE-KO ND group (Figure 1G). Here, APOE is linked to Fabry disease.