Finally, given that autophagy deregulation is implicated in many retinal pathologies related to hyperglycemia and dyslipidemia (Meng et al., 2017), we investigated if this cellular homeostatic mechanism (Kim et al., 2008; Rodriguez-Muela et al., 2012; Wen et al., 2019) was activated in FD-fed ApoE-KO mice, once retinal abnormalities were detected. This evidence concerns the gene APOE and metabolic syndrome.