As other combinations (MYD88mt/CD79Bmt, MYD88wt/CD79Bmt, MYD88wt/MYD88wt) are sensitive to ibrutinib, there is a possibility of an MYD88-dependent but BCR-independent ABC-DLBCL subtype (9). This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.