On the other hand, cells with inactivated KLHL14, a negative BCR component regulator often mutated in DLBCL, induce the NFκB pathway by activating the MYD88-TLR9-BCR super-complex, which partially protects them from ibrutinib-induced cell death (91). The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.