IL6 and Epstein-Barr virus infection: In univariate logistic regression analysis, lower CR rate was related to male, first diagnosis older than 60 years, stage III-IV, B symptoms, bone marrow involvement, IPI ≥3, ECOG ≥3, EBV infection, Extra-nodal ≥1, IL-10 ≥3.6 pg/ml, IL-6 ≥2.2 pg/ml, IFN γ ≥3.0 pg/ml, decreased LDH and decreased β2-MG (Table 2).