IL6 and glioblastoma: Concordantly, endothelial cell-specific deletion of IL-6 prevented glioma growth and improved mouse survival (46); (2) it reinforces GBM metabolic dependence on aerobic glycolysis (47), as discussed below; and (3) it promotes the recruitment of macrophages through the induction of CCL5/CXCL5 and favors their alternative activation through PPARγ/HIF-2α signaling (46).