ITGAM and influenza: While among the proteins with lower abundance, integrin alpha-M (also known as CD11b) is critical for leukocyte adhesion and migration for immune functions, small molecule-mediated activation of integrin CD11b/CD18 reduces inflammatory disease (Maiguel et al., 2011) and is associated with T-cell-mediated immune suppression by neutrophils after influenza infection (Tak et al., 2018).