In humans, polymorphisms of several inflammatory cytokines, including TNF-α, are associated with the risk of noise-related tinnitus (Doi et al., 2015; Marchiori et al., 2018; Marchiori et al., 2019), a central auditory disorder that is often comorbid with impairment in gap detection (Fournier and Hebert, 2013; Mehdizade Gilani et al., 2013). This evidence concerns the gene TNF and Tinnitus.