We found that intravenous injection of a CD4- or IFN-γ-specific antibody completely blocked the protective effects of flo8 mutant priming against CLP-induced sepsis, as shown by lower survival rates and increased bacterial burdens in the blood and peritoneal cavity compared with those of primed mice receiving control IgG (Fig. 7F–I). This evidence concerns the gene IFNG and Sepsis.