As PSMD14 is a subunit of 19S regulatory particles of 26S proteasomes and is related to protein degradation20, we examined related signaling pathways in PSMD14 knockdown in melanoma using the Molecular Signatures Database (https://www.gsea-msigdb.org/gsea/msigdb/index.jsp)16,17. This evidence concerns the gene PSMD14 and melanoma.