FFour independent regions in the genome showed evidence of association with progression to diabetes (Table 2, Fig. 1): one region attaining genome-wide significance, 20p12.1 (TASP; P < 5 x 10–8) and three regions with suggestive evidence (P < 8.5 × 10–8), 1q21.3 (MRPS21-PRPF3), 2p25.2 (NRIR), and 3q22.1 (COL6A6). This evidence concerns the gene PRPF3 and diabetes mellitus.