The results of the multivariate binary logistic regression were validated by prior knowledge from literature: (1) Sex, when compared females, males are more often diagnosed with myocardial infarction, fatal coronary heart disease, among other cardiac diseases38; (2) Age, cardiovascular disease (CVD) has been shown to increase with age across multiple populations38; (3) NSAIDs, especially preferential and selective cyclooxygenase-2 inhibitors, increase the risk of CVD39,40. The gene discussed is PTGS2; the disease is cardiovascular disorder.