PAX5 and precursor B-cell acute lymphoblastic leukemia: B-ALL appeared between 6 and 16 months of age in IL-6+/+/Pax5+/- mice (mean = 11.29 months) and, at the end of the 24 months’ experimental period, 22% of the mice had developed B-ALL (Fig. 3a-b), in line with previously reported results.