There was no significant difference in serum T4, TSH, prolactin, testosterone/estradiol levels in both the groups, whereas serum LH and FSH levels were significantly reduced [LH (p = 0.018), FSH (p = 0.002)] in acromegaly patients with diabetes in comparison to without diabetes suggesting the effect of hyperglycemia on gonadotropes, despite similar tumor volume. Here, PLOD1 is linked to Hyperglycemia.