Regarding to the significant SNPs that have odds ratios greater than 1, indicating that they are related with progressive effects towards cognitive impairment, we found out that rs935129 in RP11-81K2.1 and PHB, rs6726046 in DGKD and AC0129221.4, and rs13028996 in SAG are significant at the level less than \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$1\times 10^{-5}$$\end{document}1×10-5. This evidence concerns the gene PHB1 and Cognitive impairment.