The specific ESR1 SNP detected as associated with cognitive impairment in our study is not in linkage disequilibrium with the SNPs reported in Yaffe et al. (r2 \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\le$$\end{document}≤ 0.014) and are greater than 100 kB distant from these SNPs, therefore likely represent a different association signal. The gene discussed is ESR1; the disease is Cognitive impairment.