Out of all the significant SNPs, rs13198061 in gene ESR1, rs56368572 in CTNND2, rs954303 near RNU4-58P and rs939432 in gene RYR3 have p-values less than \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$1\times 10^{-5}$$\end{document}1×10-5 and odds ratio less than 1, indicating that those SNPs are associated with potential protective effects of preventing cognitive impairment. Here, RYR3 is linked to Cognitive impairment.