Some of the ESR1 polymorphisms associated with Alzheimer’s disease and mild cognitive impairment are low-frequency (MAF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${<}2\%$$\end{document}<2%)51. Here, ESR1 is linked to early-onset autosomal dominant Alzheimer disease.