AKT1 and cancer: Due to various gene depletion or mutation (PTEN, PI3KCA, and RTK etc), dysregulation and overactivation of phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) cascade is detected in NSCLC, which is associated with tumorigenesis and cancer progression3,4.