BCL2 and cardiovascular disorder: Moreover, apoptosis acts as another vital component of cardiomyocyte death within multiple cardiovascular disease.17 Among a wide range of receptors, Bax is generally associated with apoptosis, well Bcl-2 acts as an antiapoptotic regulator.18 Therefore, the ratio of Bcl-2/Bax is used to indicate the anti-apoptotic level.