It has also been reported that miR-638 targets HOXA9 3’UTR directly, downregulates HOXA9 expression, and thus inhibits the two Wnt signaling effectors c-Myc and Cyclin D1, while overexpression of HOXA9 can partially abolish the miR-638 effects in glioma [22]. Here, MYC is linked to central nervous system cancer.