HIF1A and colorectal cancer: Four miRNAs (miR-196a, miR-196b, miR-921 and miR-98) were identified that might bind to 3′ UTR of HIF-1α. Among which, a low miR-196b-5p expression is significantly associated with metastases and poor survival in patients with colorectal cancer, while miR-196b-5p inhibition leads to significantly increased colorectal cancer cell migration/invasion and metastases [34].