MYC and cancer: Shunting of some of this glucose to HBP in both cell types could provide signals for increased cell proliferation through protein O-GlcNAcylation of pluripotency genes such as Oct4 and c-Myc, whereas O-GlcNAcylation of SOX2 at S248 is inhibitory to pluripotency suggesting that O-GlcNAcylation of pluripotency-related transcription factors is complex and in need of further investigation to fully understand its role in normal and cancer cell self-renewal.