LDLR and cardiovascular disorder: Mutations in LDLR as well as genes encoding apolipoprotein B and LDLR adaptor protein 1 (also known as autosomal recessive hypercholesterolemia), which are involved in LDL–LDLR binding and LDL–LDLR complex endocytosis, respectively, confer elevated levels of plasma LDL-cholesterol (LDL-C) that eventually increase the risk for cardiovascular disease (3, 4).