In this study, we found that TM4SF1 expression was markedly higher in CRC tissues than in non-tumour tissues and was positively correlated with depth of invasion, T stage, lymph node metastasis, and distant metastasis in patients with CRC, which suggested that TM4SF1 may serve as a potential biomarker to predict the metastasis and prognosis of CRC. Here, TM4SF1 is linked to colorectal carcinoma.