MTOR and neoplasm: One patient with a hypothalamic pilomyxoid astrocytoma developed tumor recurrence along a previous left frontal biopsy tract, which was subsequently biopsied (20 months after diagnostic surgery and following successive treatment with chemotherapy, a MEK inhibitor (trametinib), and an mTOR inhibitor); both primary and recurrent metastatic specimens remained positive for BRAF fusion and negative for BRAFV600E (Patient #7, Fig. 1).