Other temporal genomic changes (CDKN2A deletion, ATRX loss, TP53 mutations) in one patient with an IDH1-mutant diffuse astrocytoma: The aforementioned patient with an IDH1-mutant (R132H) diffuse astrocytoma (Patient #33, Fig. 1) was found to have several genetic changes at recurrence and following radiotherapy, including loss of a hemizygous CDKN2A deletion (initially tested positive). Here, IDH1 is linked to diffuse astrocytoma.