Additionally, two somatic mutations in TP53 (E258G, R267W) were detected at diagnosis and conserved at recurrence; however, additional unique TP53 alterations were identified in this patient’s tumor samples, which were not shared (del exons 2–4, K132Q, N131del, R248W in the primary diagnostic sample, and R273C and E285* [both subclonal] in the recurrent sample), indicating possible loss and acquisition of these aberrations, respectively. This evidence concerns the gene TP53 and neoplasm.