CDKN2A and neoplasm: The third patient had three tumor samples available for CDKN2A testing; CDKN2A deletions were conserved in the first two tumor samples (which were obtained 14 months apart and following chemotherapy), but no CDKN2A deletion was identified in the final specimen, obtained at autopsy approximately 7 years later and following further systemic therapy plus irradiation (Patient #5, Fig. 1).