Additionally, in two studies of pediatric LGGs which underwent malignant transformation, while CDKN2A loss was identified in a majority of tumors at diagnosis and conserved over time, two of 16 paired tumor specimens gained CDKN2A deletions at the time of evolution to HGG (one of eight from each report) [9, 40]. The gene discussed is CDKN2A; the disease is neoplasm.