For example, the dysregulation of CASQ2, which is known to amplify the likelihood of diastolic SR Ca2+ releases by relieving its inhibitory effects on cardiac-specific ryanodine receptor 2 (RyR2) during diastole, and downregulation of RYR2 could work collectively to increase the probability of ventricular arrhythmias [31]. Here, RYR2 is linked to Ventricular arrhythmia.