Since miR-142-3p and ROCK2, downstream of circCUL2, could be relevant to GC prognosis [17, 18], we analyzed the TCGA database and found that higher expression of miR-142-3p and lower expression of ROCK2 resulted in shorter disease-free survival (DFS) or DFS combined with chemotherapy (Fig. 6a-b). Here, ROCK2 is linked to gastric cancer.