DLEC1 and squamous cell carcinoma: However, an abnormal methylation profile (like DLEC1 hypermethylation) is significantly linked to head and neck, ovarian, lung, renal, nasopharyngeal, oral, adrenocortical, hepatocellular, esophageal, gastric, and squamous cell carcinoma [11, 28, 30–32, 38, 39, 53, 54, 56–64].