Nevertheless, overexpression of EphB4 in A375 melanoma cells also influenced expression of 9 angiogenesis-related proteins (Ang-1, VEGF, Akt/PKB, TIMP-1, TIMP-2, TIMP-3, IL-8, TGF-β2, TGF-β R3). This evidence concerns the gene TGFB2 and melanoma.