With regard to (tumor) angiogenesis-related proteins (highlighted in red), we found differences in VEGF, angiotensin 1 (Ang-1), interleukin-8 (IL-8), transforming growth factor beta-2 (TGF-β2), transforming growth factor beta receptor 3 (TGF-β R3), as well as in tissue inhibitor of metalloproteinase-1, -2, and -3 (TIMP-1, TIMP-2, and TIMP-3) expression between A375-pIRES and A375-EphB4 cells (Figure 5a, Supplementary Figure S8b). The gene discussed is TIMP2; the disease is neoplasm.