These studies showed that RT-QuIC could detect misfolded α-synuclein in the CSF or olfactory mucosa of patients with PD, MSA and DLB [124,125,126,130,131], misfolded tau in the CSF of patients with PiD [132], CBD and PSP [128], and misfolded TDP-43 in the CSF of patients with FTD and ALS [129]. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.