The inhibition of aromatase mRNA transcription by microRNA was described in tissues of mammalian ovaries (miR-503 and miR-378, direct activity; miR-224 and miR-383, indirect activity), in the differentiation of trophoblasts (miR-19b and miR-106a), and in endometrial cancer (miR98) [141]. The gene discussed is CYP19A1; the disease is endometrial cancer.