CD4 and neoplasm: One of the main functions of DCs is the recognition of tumor cells, by processing and presenting tumor antigens through the MHC-II and MHC-I, leading in turn to the activation of CD4+ and CD8+ T lymphocytes, respectively, in response to environmental cytokines such as IL-12, TNF-α and IFN-γ produced by NK and NKT cells and macrophages [117].