CD4 and tuberculosis: GamTBvac and other novel TB-vaccine candidates (MVA85 A, H56:IC31, H1:IC31, M72/AS01 E) showed related response profiles: CD4+ responses were higher than CD8+ T-cell responses, except AERAS-402 where the main response detected were polyfunctional and INF-γ+ expressing CD8+ T-cells [24].