Particularly, aberrant signal transduction through the RAS/RAF/MEK/ERK axis has been repeatedly implicated in a multitude of malignancies, including melanoma [9], non-small cell lung carcinoma [10], colorectal cancer [11], papillary thyroid cancer [12], glioma [13], and hematological malignancies [14,15,16,17]. Here, MAP2K7 is linked to melanoma.