MAP2K7 and familial atrioventricular septal defect: Since the MAPK/ERK pathway activation has been previously shown to enhance LIN28a stabilization, which in turn reduced the expression of the let-7 family miRNAs [51], we analyzed the expression of let-7a-5p, let-7b-5p, let-7c-5p, let-7d-5p, and let-7g-5p in eight ECD patients who were effectively treated with a MEK inhibitor (cobimetinib) and one patient (ECD28) treated with BRAF inhibitor (vemurafenib).