From a total of 7175 skin cancers, 12 MCCs (0.17%) spanning the period 2009–2019, histologically diagnosed by immunoreactivity for neural cell adhesion molecule (CD56), cytokeratin 20 and cytokeratin AE1/AE3 were selected from the San Salvatore Hospital Department of Pathology database (L’Aquila, Italy). This evidence concerns the gene KRT20 and skin cancer.