Our preliminary results, obtained in 28 COVID-19 patients, showed the clear presence of mucosal IgA in the tears of COVID-19 patients with different degree of symptoms and disease stage, suggesting that deepening the investigation on IgA role in the disease may open new perspectives for SARS-CoV-2 patient treatment and that IgA detection may be used as a potential diagnostic/prognostic marker. This evidence concerns the gene CD79A and COVID-19.