MCM2 and neoplasm: Furthermore, a positive correlation between tumor nodule growth and Ki67 signal in both untreated and treated mice (Pearson’s correlation values 0.39 (t test 0.0001) and 0.53 (t test 0.0001), respectively) was observed, although its extent was moderate indicating that Ki67 is less sensitive than MCM2 and CA9 (both strongly correlated to tumor growth index) in the prognosis of tumor progression (Figure 5G,H).