Since the positivity to Tunel reaction (apoptosis), Ki67 (proliferation), and GD2 (malignant potential) are canonically considered for the evaluation of tumor dangerousness, we tested their correlation with tumor nodules growth and compared it with the same parameter obtained from MCM2 and CA9 in order to further clarify their key role in NB progression. The gene discussed is MCM2; the disease is neuroblastoma.