SDHB and hereditary clear cell renal cell carcinoma: Although specific mechanisms such as the one elucidated for GISTs are not yet available, research has implicated SDHB and SDHD [44] mutations in renal cell carcinoma and thyroid tumors, SDHB defects [45] in pituitary adenomas, and loss of SDHB [46] in hemangioblastoma.