However, among Tat(+) mice the RU-486-induced increase in corticosterone was present (p < 0.0001; Figure 3D; see #), but significantly attenuated compared to that observed in Tat(−) controls (p < 0.0001–0.0006; Figure 3D; see *), further supporting a Tat-induced adrenal insufficiency. Here, TAT is linked to Adrenal insufficiency.