PDIA3 and cancer: By analyzing the role of PDIA3 in GB survival using The Cancer Genome Atlas (TCGA) database (https://xenabrowser.net/, accessed on 2 November 2020), 352 out of 690 patients (dataset: TCGA lower grade glioma and GB) showed increased PDIA3 expression in the tumor tissue that was associated with an approximately 55% reduction of overall survival compared to patients with lower PDIA3 levels (Figure 1).