PDIA3 and central nervous system cancer: Moreover, in order to study the inflammatory response of glioma cells, we studied the effects of PDIA3 downregulation in T98G cells exposed 4 h stimulation with a pro-inflammatory cytokine mix (i.e., TNFα, IL1β, and hIFNγ, hereafter referred to as TII) followed by 3 washes and 24 h incubation with fresh media before collection of the culture supernatant (hereafter referred to as the pS-CM, condition that mimics a late stage of GB pathology.