One study on children with recent-onset T1D identified six miRNAs (miR-454-3p, miR-222-3p, miR-144-5p, miR-345-5p, miR-24-3p, and miR-140-5p) with high expression only in the early stages of diabetes; moreover, pathway analysis associated this pattern of differential miRNA expression with glycosaminoglycan biosynthesis as well as with PI3K/Akt, MAPK, and Wnt signaling pathways in early T1D [54]. Here, PIK3CA is linked to type 1 diabetes mellitus.