BRAF and colorectal carcinoma: In MSI-H CRCs, controversial conclusions were drawn: some studies concluded that the BRAF mutation did not have an association with a poor prognosis in MSI-H/dMMR group CRC [22,25,26,27,28,45,87,88], but the others concluded that the negative impact of the BRAF mutation was observed regardless of MSI/MMR status [24,46,89].