Pilot studies carried out by Young et al. have also demonstrated that tumors resulting from the implantation of mouse B16 melanoma cells into mice with inhibited SOX18 expression as well as mice exhibiting a mutated inactive form of SOX18 grew more slowly and characterized themselves by having a lower vascularization density than those tumors with a fully preserved SOX18 function implanted in control mice [150]. The gene discussed is SOX18; the disease is melanoma.