INS and obesity due to melanocortin 4 receptor deficiency: For this reason, the present study was focused on exploring the cross-sectional association among the most commonly used anthropometric parameters, namely BMI, WC, WHtR and NC and the CV risk factors mainly evaluated in clinical practice, such as systolic and diastolic blood pressure, and fasting glucose, lipid (triglycerides, total, HDL and LDL cholesterol), insulin, HOMAIR [18], uric acid, 25-hydroxyvitamin D (25(OH)D) [19], C-reactive protein (CRP), white blood cells and platelets numbers in a population of 1214 apparently healthy subjects with overweight and obesity.