APLN and herpes simplex infectious disease: The enriched pathways included metabolic pathways, herpes simplex infection, influenza A, cell cycle, apelin signaling pathway, ubiquitin mediated proteolysis, neuroactive ligand-receptor interaction, cell adhesion molecules, tight junction, cellular senescence, FoxO signaling pathway, glycerophospholipid metabolism, peroxisome proliferator activated receptor (PPAR) signaling pathway, etc. (Table 4).