DNM1L and familial pancreatic carcinoma: Although deleting DNM1L does not affect OXPOS and mtDNA synthesis in mouse embryonic fibroblasts [6], our results are similar to those of pancreatic cancers [11] and revealed that the loss of DRP1 in lung adenocarcinoma cell lines leads to increased mitophagy to mitochondrial damage and decreased OXPHOS and mtDNA copy numbers.