Anti‐PD‐1 and anti‐CTLA‐4 each suppressed the growth of DLM8 osteosarcoma compared to vehicle control, leading to respective TGI of 57% (P < .01) and 79% (P < .0001) and 86% (P < .0001) for the combination. The gene discussed is CTLA4; the disease is osteosarcoma.