Combination therapy with BEMPEG and anti‐CTLA‐4 was especially effective, preventing significant tumor outgrowth of established primary tumor in 100% of treated animals in the DLM8 model for up to 141 days posttreatment initiation (Figure 5), with 100% surviving animals of which 60% were tumor free (Table 1). This evidence concerns the gene CTLA4 and neoplasm.